Boehringer Ingelheim Scientist III/IV, Drug Concept Discovery, Immunology & Respiratory in RIDGEFIELD, Connecticut
Boehringer Ingelheim is an equal opportunity global employer who takes pride in maintaining a diverse and inclusive culture. We embrace diversity of perspectives and strive for an inclusive environment which benefits our employees, patients and communities.
Candidate will be hiredat level commensurate with experience
Scientist III/IV,Drug Concept Discovery, Immunology & Respiratory
The Immunology & Respiratory Department is seeking a talented and innovative Scientist III/IV to join our DrugConcept Discovery research team in Ridgefield, CT. The successful candidate will collaborate with a passionate and energetic team of scientists striving to build a transformative portfolio of innovative small molecule and biologics based therapeutics.
Performs routine lab duties without supervision. Designs and executes non-routine experiments on a basis of literature analyses with minimal supervision. Assists in supervising/training technicians and junior scientist. Performs all work in conformance with applicable regulations. Performs all work in a safe manner. The primary scope of responsibility is within the immediate discipline and secondarily within a multi-disciplinary environment.
As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer-Ingelheim's high regard for our employees.
Duties & Responsibilities:
Initiates and completes routine invitro molecular, cellular and pharmacology assays in an independentefficient manner including effective troubleshooting and operation andmaintenance of lab equipment
Proposes, designs and executesnon-routine drug concept discovery biology experiments based onindependent literature analyses with minimal supervision
Proposes new experiments andtechnology advancements based on expertise in field and overallunderstanding of drug discovery/development process
Independently applies basicscientific knowledge, attends internal and external scientific meetingsand keeps abreast of relevant scientific literature to support work
Contributes to training of colleagues,independently operates lab equipment and takes responsibility for properlab instrumentation usage and maintenance
Effectively communicates anddefends own work at team meetings(orally and in writing)
Reports and treats data with a highlevel of integrity and ethics, including writing clear protocols, procedures,and technical reports.
Maintains data notebooks accordingto company guidelines and provides input for departmental scientificreports and audits
Complies with applicableregulations, performing all work in a safe manner and maintains properrecords in accordance with SOPs and policies
Supports and embraces diversityas an employee and representative of BIPI
Scientist III Requirements:
- Master’s degree from anaccredited institution in Immunology, Cell Biology, Biochemistry, Pharmacology,or related discipline with at least 3+ years relevant lab researchexperience or Bachelor’s degree from an accredited institution inImmunology, Cell Biology,Biochemistry, Pharmacology, or related discipline with 7+ years relevantlab research experience.
- Master’s degree from anaccredited institution in Immunology, Cell Biology, Biochemistry, Pharmacology,or related discipline with at least 6+ years relevant lab researchexperience or Bachelor’s degree from an accredited institution inImmunology, Cell Biology,Biochemistry, Pharmacology, or related discipline with 10+ years relevantlab research experience.
Core competencies requiredinclude solid knowledge in cellular and molecular biology with expertise inin vitro pharmacology, immunology and advance cell co-culture models.
Proficient with mammalian cell culturetechniques; experience establishing complex co-culture systems andinterrogating pathways in cell lines and primary human/rodent immune,epithelial and stromal cells (2D and 3D-culture cell-based assays, mixed-cellco-culture and/or organoid models) is highly desired.
Hands on experience with DNAtransfection and/or retroviral transduction methods for in vitro mammaliancell culture models.
Proficient with cellular modelsto study phagocytosis/efferocytosis and associated pathways is a plus.
Solid hands-on experienceapplying multicolor flow cytometry and related analytical techniques forprimary cell isolation and to phenotypically characterize cell responses(intracellular cytokines & phosphoprotein staining, cell viability& proliferation).
Demonstrated experience inDNA/RNA isolation, qRT-PCR/TaqMan (single and multiplex analytes), Nanostringand/or RNAseq.
Adept at designing anddeveloping sophisticated cell-based assays with minimal supervision.
Highly skilled at applyingstate-of-the-art molecular/cell biological, biochemical and immunologicalmethods to measure pre-defined endpoints such as: cytokine and/or matrixproduction, cell migration, proliferation, apoptosis, cytotoxicity,phagocytosis, reporter gene activities, and/or molecular signaltransduction pathways in response to stimuli or agonists.
Hands on experience with adiverse set of molecular and cell biology approaches (e.g. Incucyte, ELISA,MesoScale, In-Cell ELISA, FACS, ImageStream, TaqMan, Luminex, SDS PAGE/immunoblotting).
Good lab hygiene and organizationskills; excellent communication skills and impactful problem solvingabilities.
Experience outsourcing basicmolecular biology and reagent production activities.
Working knowledge of computersoftware including MS Word, Excel, PowerPoint and additional scientificanalysis software (e.g. SpotFire, Prizm GraphPad, FloJo XL-Fit orcomparable scientific, bioinformatics or statistical data applications).
Passionate about science andadept in a fast-paced, nimble, team-based work setting.
Supplemental technical coursesin area of expertise
Ability to operate laboratoryequipment with independence
Ability to draft technicalreports
Demonstrate written and verbalcommunication skills
Concise and accurate reportingof technical data and interpretation thereof
Proven problem solving ability
Able to act for supervisor inhis/her absence
Appropriate level ofunderstanding of applicable regulations
Must be legallyauthorized to work in the United States without restriction.
Must be willing totake a drug test and post-offer physical (if required)
Must be 18 years ofage or older
Boehringer Ingelheim is a different kind of pharmaceutical company, a privately held company with the ability to have an innovative and long term view. Our focus is on scientific discoveries that improve patients' lives and we equate success as a pharmaceutical company with the steady introduction of truly innovative medicines. Boehringer Ingelheim is the largest privately held pharmaceutical corporation in the world and ranks among the world's 20 leading pharmaceutical corporations. At Boehringer Ingelheim, we are committed to delivering value through innovation. Employees are challenged to take initiative and achieve outstanding results. Ultimately, our culture and drive allows us to maintain one of the highest levels of excellence in our industry. Boehringer Ingelheim, including Boehringer Ingelheim Pharmaceuticals, Inc., Boehringer Ingelheim USA, Boehringer Ingelheim Animal Health USA, Inc., Merial Barceloneta, LLC and Boehringer Ingelheim Fremont, Inc. is an equal opportunity and affirmative action employer committed to a culturally diverse workforce - Minority/Female/Protected Veteran/Person with a Disability. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
Boehringer Ingelheim is firmly committed to ensuring a safe, healthy, productive and efficient work environment for our employees, partners and customers. As part of that commitment, Boehringer Ingelheim conducts pre-employment verifications and drug screenings.
Organization: US-BI Pharma/BI USA
Title: Scientist III/IV, Drug Concept Discovery, Immunology & Respiratory
Location: Americas-United States-CT-Ridgefield
Requisition ID: 185781