Boehringer Ingelheim Post Doctoral Scientist - Human Genetics in RIDGEFIELD, Connecticut
Boehringer Ingelheim is an equal opportunity global employer who takes pride in maintaining a diverse and inclusive culture. We embrace diversity of perspectives and strive for an inclusive environment which benefits our employees, patients and communities.
Post Doc – Human Genetics
Boehringer Ingelheim is currently seeking a driven and innovative Postdoctoral Scientist in Quantitative Genetics and Genomics to join our Cardio-Metabolic Disease Research department located at our Ridgefield, CT facility.
As a Postdoctoral Scientist, you will be focusing your research on understanding the molecular bases of disease progression in the field of Nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH). Your research project is part of a collaborative effort involving academic institutions as well as industrial partners and you will be driving research in the areas of genetics, functional genomics and systems biology from a computational perspective by identifying or developing appropriate tools and methods to identify novel therapeutic opportunities. A key focus will be to identify novel genes and provide supporting evidence for causality, mechanistic involvement in tissue and druggability perspective. You will leverage not only data generated by the collaboration, but also additional internally available datasets, publicly available cohorts as well as data from in-vitro and in-vivo model systems. You will be performing analyses that comprehensively model genetic background information with single-cell level expression data from different tissues. As a postdoctoral scientist you will be expected to independently conduct research and publish findings in scientific journals.
The ideal candidate is a data scientist with research interest and familiarity in integrating and interpreting the results of analyses coming from large and diverse sources including genetic, bulk and single cell expression and clinical data.
As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.
Perform genetic analysis (traitassociations, variant calling, eQTL, mQTL etc.) and transcriptomicanalysis (RNA-seq, single cell RNA-seq, ASE etc.)
Independently conduct a researchproject and effectively communicate the results and findings internallyand externally
Perform network analysis (e.g.WGCNA, master regulators etc.)
Perform/develop integrative multi-omcis scale data analyses
Identify novel genes and pathwaysand develop a testable therapeutic concept
Work in a collaborative researchenvironment
Desired Experience,Skills and Abilities:
· Proven experience in conducting and publishing creative and innovative research projects
Strong knowledge of geneticsrelated analyses (GWAS, m/eQTL, PrediXcan etc.)
Strong experience in quantitativegenomics (bulk and single cell gene expression, network analysis)
Experience with analyticallyintegrating and interpreting results from different data sources (e.g.GEO, ArrayExpress, GWAS Catalogue, GTEx etc.)
Good knowledge of biology andmolecular basis of pathology and familiar with methodologies forexperimental validation
Fluent in statistical analysis (Rpreferred)
Familiar with analysis ofepigenetic modifications (methylation, ATAC-seq etc.)
Familiar with command line tools (e.g.bash or perl etc.) and genetic relevant packages (plink, GATK etc.)
Familiar with cluster computing
PhD degree in genetics, systemsbiology or related quantitative biology disciplines with no more than 3years of postdoctoral experience
Good written and oral communicationskills
Must be legally authorized towork in the United States without restriction.
Must be willing to take a drugtest and post-offer physical (if required)
Must be 18 years of age orolder
Boehringer Ingelheim is a different kind of pharmaceutical company, a privately held company with the ability to have an innovative and long term view. Our focus is on scientific discoveries that improve patients' lives and we equate success as a pharmaceutical company with the steady introduction of truly innovative medicines. Boehringer Ingelheim is the largest privately held pharmaceutical corporation in the world and ranks among the world's 20 leading pharmaceutical corporations. At Boehringer Ingelheim, we are committed to delivering value through innovation. Employees are challenged to take initiative and achieve outstanding results. Ultimately, our culture and drive allows us to maintain one of the highest levels of excellence in our industry. Boehringer Ingelheim, including Boehringer Ingelheim Pharmaceuticals, Inc., Boehringer Ingelheim USA, Boehringer Ingelheim Animal Health USA, Inc., Merial Barceloneta, LLC and Boehringer Ingelheim Fremont, Inc. is an equal opportunity and affirmative action employer committed to a culturally diverse workforce - Minority/Female/Protected Veteran/Person with a Disability. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
Boehringer Ingelheim is firmly committed to ensuring a safe, healthy, productive and efficient work environment for our employees, partners and customers. As part of that commitment, Boehringer Ingelheim conducts pre-employment verifications and drug screenings.
Organization: US-BI Pharma/BI USA
Title: Post Doctoral Scientist - Human Genetics
Location: Americas-United States-CT-Ridgefield
Requisition ID: 184624